Current approaches to osteoarthritis phenotyping

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Computational approaches to phenotyping: high-throughput phenomics.

The recent completion of the Human Genome Project has made possible a high-throughput "systems approach" for accelerating the elucidation of molecular underpinnings of human diseases, and subsequent derivation of molecular-based strategies to more effectively prevent, diagnose, and treat these diseases. Although altered phenotypes are among the most reliable manifestations of altered gene funct...

متن کامل

Current trends of stem cell-based approaches for knee osteoarthritis

Introduction Osteoarthritis (OA) is the most prevalent joint disorder resulting in cartilage destruction, subchondral sclerosis, osteophyte formation, and synovitis. Knee osteoarthritis presents a great clinical challenge to clinicians due to the limited inherent repair capacity of avascular, aneural articular cartilage. Articular cartilage defects are increasingly common among the elderly caus...

متن کامل

Post-Traumatic Osteoarthritis: Biologic Approaches to Treatment

Joint injuries are becoming increasingly common, with young adults between the ages of 1844 seeking medical attention for joint sprains, dislocation, fractures, anterior cruciate ligament (ACL) and meniscal tears, and others. The cascade of events that follow these joint injuries have been shown to increase the risk of post-traumatic osteoarthritis (PTOA) by 2050% (Anderson et al,2011). Therefo...

متن کامل

Metabolic phenotyping and systems biology approaches to understanding neurological disorders

The development of high-throughput metabolic profiling and the study of the metabolome are particularly important in brain research where small molecules or metabolites play fundamental signalling roles: neurotransmitters, signalling lipids, osmolytes and even ions. Metabolic profiling has shown that metabolic perturbations in the brain go beyond alterations of neurotransmission and that variat...

متن کامل

Current Approaches to Change Blindness

Across saccades, blinks, blank screens, movie cuts, and other interruptions, observers fail to detect substantial changes to the visual details of objects and scenes. This inability to spot changes (“change blindness”) is the focus of this special issue of Visual Cognition . This introductory paper briefly reviews recent studies of change blindness, noting the relation of these findings to earl...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Modern Rheumatology Journal

سال: 2019

ISSN: 2310-158X,1996-7012

DOI: 10.14412/1996-7012-2019-2-4-8